Synthesis, Characterization and Antidiabetic Activity of New Pyrimidine Fused Derivatives
DOI:
https://doi.org/10.22270/ijmspr.v8i2.37Keywords:
diabetes mellitus, anti-diabetic activity, pyrimidine derivatives, Noevenagel CondensationAbstract
Various evidences suggest that common health problem of modern society, viz. diabetes mellitus, obesity, cardiovascular diseases etc. The prevalence of diabetes mellitus in majority increases with age and obesity; over 20 % adults (≥ 60 years or older) have diabetes. Synthesis of starting materials by Noevenagel Condensation then A reaction mixture of different benzylidine propanednitriles 1a-d (10 mmol), alkylisothiourea salts (11.00 mmol) and sodium acetate anhydrous (2.50 g, 24.40 mmol) in pyridine (50 ml) was refluxed for 3 hrs, and crystallized from ethanol give compound 2a-d. then 2-Methylthiopyrimidines 2a-d (5.0 mmol) was heated under reflux overnight with 5 mL of the appropriate amine (2-phenylethylamine or cyclohexylamine, and crystallized from appropriate solvent give compound 3a-d. synthesized derivatives characterized by IR, NMR and Mass spectrophotometry and evaluated for anti-diabetic activity.
Keywords: diabetes mellitus, anti-diabetic activity, pyrimidine derivatives, Noevenagel Condensation.
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